ISO 10121 Part 1
ISO 10121 Part 1 anchors laboratory challenge testing for gas-phase air-cleaning media used in general ventilation.
AlignedStandards
Gas-Phase FiltrationISO 10121 Part 1ASHRAE 145.2
Standards for VOC breakthrough testing of gas-phase filters, sorbent media, and air-cleaning devices.
Removal efficiency, breakthrough behavior, capacity, and upstream and downstream gas measurements can support product development, product comparisons, or claims review.
Standard roster
Individual standards in this cluster
ISO 10121 Part 1, ISO 10121 Part 2, and ASHRAE 145.2 form the citation set; ARE Labs translates them into challenge-gas control, sampling points, breakthrough analysis, and report evidence.
ISO 10121 Part 2
ISO 10121 Part 2 applies to objective testing of full-size gas-phase air-cleaning devices for general ventilation.
AlignedASHRAE 145.2-2025
ASHRAE 145.2-2025 frames full-scale laboratory testing of in-duct gas-phase air-cleaning devices.
AlignedPurpose & when to use
Gas-phase filtration and sorbent breakthrough studies expose media or devices to a controlled gas challenge and track upstream and downstream concentrations over time. This standards cluster helps teams determine how ISO 10121 Part 1, ISO 10121 Part 2, and ASHRAE 145.2 apply to VOC removal efficiency, breakthrough behavior, capacity, and product comparisons:
- Sorbent-media teams use ISO 10121 Part 1 when media geometry, gas challenge, and breakthrough curves need a reviewable comparison basis.
- Full-size device programs use ISO 10121 Part 2 when upstream/downstream measurements and device-level removal efficiency drive the claim.
- In-duct air-cleaning devices use ASHRAE 145.2 when duct fixture design, gas dispersion, and performance reporting must align.
- Hybrid or nonstandard systems use ISO and ASHRAE references to document fit-for-purpose deviations, analytical methods, and reporting limits.
Use this cluster when the decision requires more than a single removal-efficiency result. The study record then needs to connect challenge generation, airflow, media or device configuration, analytical measurement, the defined breakthrough point, capacity estimates, and documented departures from the reference method.
Applicable to
Built around gas-phase removal decisions
The cluster applies when VOC or gas-removal claims depend on controlled challenge delivery, air-path geometry, analytical measurement, and time-resolved breakthrough data.
Standards in this group
What each citation controls
This page treats the citations as a cluster, not a substitute for the standards themselves. ISO 10121 Part 1 addresses gas-phase air-cleaning media, ISO 10121 Part 2 addresses full-size gas-phase devices, and ASHRAE 145.2 addresses in-duct gas-phase air-cleaning devices. ARE Labs uses the official source status and the product configuration to set the study frame.
ISO
AlignedISO 10121 Part 1
Test method for assessing the performance of gas-phase air cleaning media and devices for general ventilation - Part 1: Gas-phase air cleaning media
ISO 10121 Part 1 anchors laboratory challenge testing for gas-phase air-cleaning media used in general ventilation. ARE Labs uses it to frame media holder configuration, challenge-gas selection, steady-state conditions, breakthrough curves, and like-for-like comparison of sorbent media configurations.
ISO official page verified 2026-05-17; page lists Edition 1, 2014-04, published status, and expected FDIS replacement.
ISO
AlignedISO 10121 Part 2
Test methods for assessing the performance of gas-phase air cleaning media and devices for general ventilation - Part 2: Gas-phase air cleaning devices (GPACD)
ISO 10121 Part 2 applies to objective testing of full-size gas-phase air-cleaning devices for general ventilation. ARE Labs maps it to device installation, airflow, upstream and downstream sampling, removal efficiency, capacity estimates, and stated limits when the product differs from the reference apparatus.
ISO official page verified 2026-05-17; page lists Edition 1, 2013-04, published status, and expected FDIS replacement.
ASHRAE
AlignedASHRAE 145.2-2025
Laboratory Test Method for Assessing the Performance of Gas-Phase Air Cleaning Systems: Air Cleaning Devices
ASHRAE 145.2-2025 frames full-scale laboratory testing of in-duct gas-phase air-cleaning devices. ARE Labs uses it for duct fixture planning, gas dispersion, upstream and downstream concentration measurement, calculation framing, reporting structure, and clear exclusion of stand-alone room-air-cleaner claims when applicable.
ASHRAE official TPS page verified 2026-05-17; page lists ANSI/ASHRAE Standard 145.2-2025 as published and superseding 145.2-2016.
Aligned standards, documented quality controls
ARE Labs treats this cluster as standards-aligned work unless a separate project scope says otherwise. The compliance posture separates ISO and ASHRAE method alignment from ISO 17025 quality-system language used for traceability, review, and records.
- ISO 10121-1:2014AlignedMedia breakthrough reference followed by protocol.
- ISO 10121-2:2013AlignedDevice-level performance reference followed by protocol.
- ASHRAE 145.2-2025AlignedIn-duct gas-phase device reference followed by protocol.
Operational chain
How ARE Labs turns the standards into a study
The standard citation identifies the reference frame, but the executable method still depends on product geometry, target gas, airflow, humidity, residence time, and analytical endpoint. ARE Labs translates ISO and ASHRAE expectations into controlled setup, sampling, measurement, and reporting decisions.
01
Configuration
Select the media or device path
We map ISO 10121 Part 1, ISO 10121 Part 2, or ASHRAE 145.2 to the sample holder, duct fixture, airflow, sampling points, and gas challenge.
Protocol setup02
Gas control
Stabilize the challenge
Target concentration, humidity, temperature, flow, residence time, and gas delivery are controlled so the ISO or ASHRAE frame is visible in the run record.
Challenge log03
Measurement
Capture upstream and downstream data
FTIR, GC/MS, or other analytical outputs are selected by gas and matrix, then linked to ISO or ASHRAE removal-efficiency and breakthrough objectives.
Analytical data04
Adaptation
Document nonstandard configurations
When a hybrid device or room-air format does not fit ISO 10121 or ASHRAE 145.2 cleanly, deviations and rationale are recorded before testing.
Rationale log05
Reporting
Connect results to the claim
Reports tie concentration over time, breakthrough point, removal efficiency, capacity estimates, by-products, and limitations back to the selected ISO or ASHRAE reference.
Review-ready reportData quality, QA/QC & documentation
A breakthrough curve is difficult to interpret without records documenting the gas challenge, test article, airflow, and analytical system. ARE Labs pairs ISO and ASHRAE method alignment with traceable setup checks, calibration or verification records, retained raw data, documented deviations, and QA review when requested.
Lock the challenge conditions
ISO 10121 studies record target gas, concentration, humidity, temperature, flow, stabilization checks, and gas-delivery equipment used for the run.
Preserve the fixture setup
ASHRAE 145.2 work documents duct fixture, device installation, sampling locations, airflow path, and configuration changes before data collection.
Connect instruments to endpoints
ISO and ASHRAE outputs from FTIR, GC/MS, or other instruments are reviewed against study-specific QC criteria and calibration references.
Explain method departures
When product geometry or claims do not map cleanly to ISO 10121 or ASHRAE 145.2, the protocol records rationale and limits.
Package results for decision review
ISO 17025 records connect raw concentration data, calculations, chain of custody, exclusions, deviations, and final report statements.
Why ARE Labs
ARE Labs connects technical topics to practical study design, method selection, controlled aerosol work, and reportable evidence without turning technical pages into sales pages.
Reviewed byJamie Balarashti - Weston Schaper
QualityDocumented study records
900+Studies Performed
17+Years in operation
300+Clients supported
Common questions
Choosing among ISO 10121 Part 1, ISO 10121 Part 2, ASHRAE 145.2, and a fit-for-purpose protocol starts with the product format, airflow geometry, target gas, and intended claim. These questions show how product, filtration, and air-treatment teams use those details to select the study framework before ARE Labs drafts the method and reserves the necessary analytical resources.
Q. Which citation applies?
A. ISO 10121-1 applies to media-level work, ISO 10121-2 to full-size gas-phase devices, and ASHRAE 145.2 to in-duct gas-phase air-cleaning devices. Product format and intended claim guide the choice.
Q. Is ASHRAE 145.2 current?
A. The official ASHRAE TPS page lists ANSI/ASHRAE Standard 145.2-2025 as published and superseding 145.2-2016. ARE Labs confirms the edition cited for each project based on its scope.
Q. Does ARE Labs certify devices?
A. No. ARE Labs performs testing aligned with the selected ISO or ASHRAE reference where applicable. Certification, listing, or approval remains with the relevant authority or certification body.
Q. What if my device is nonstandard?
A. ARE Labs can develop a fit-for-purpose protocol when the geometry, airflow, target gas, or product type does not map cleanly to ISO 10121 or ASHRAE 145.2.
Q. What data do we receive?
A. Reports can document the test configuration, challenge conditions, upstream and downstream concentrations, removal efficiency, breakthrough behavior, capacity estimates, by-products, deviations, QA/QC notes, and analytical outputs.
Related services & devices
Related services & devices
Service
Gas & VOC Destruction / Removal
Primary service route for VOC removal, gas-phase destruction, breakthrough, and capacity studies.Read more ->ServiceGas Delivery & Control
Challenge-gas generation, flow control, concentration setup, and exposure-condition support.Read more ->ServiceVOC & By-Product Emissions
Analytical route for VOCs, reaction by-products, and air-device emissions measurements.Read more ->ServiceAir Device Safety Panel
Adds ozone, particles, VOCs, and by-product checks around active air-treatment devices.Read more ->ServiceFiltration Efficiency
Particulate filtration route when gas-phase removal sits beside aerosol capture claims.Read more ->ServiceClean Air Delivery Rate (CADR)
Room-air-cleaner performance route for chamber-based clean-air delivery questions.Read more ->DevicesFilter Media & Standalone Filters
Media, cartridges, and filter elements evaluated for VOC breakthrough or removal behavior.Read more ->DevicesIn-Line Duct Air Treatment Systems
Duct-mounted systems where ASHRAE 145.2 fixture and sampling decisions are central.Read more ->DevicesPortable Room Air Purifiers
Room devices that may need VOC removal, emissions, CADR, or safety-panel evidence.Read more ->DevicesWhole-Room / Large Air Cleaners
Larger air-treatment systems evaluated with chamber, duct, or hybrid gas-removal protocols.Read more ->Related clusters
Related standards clusters
Gas-phase filtration work often overlaps with gas generation, VOC measurement, room-air cleaner performance, and particulate filtration standards. These neighboring clusters help route the next standards question without mixing service and citation pages.
Standards - Live